A standard clot method for the assay of plasminogen activators, anti-activators, and plasmin

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A Standard Clot Method for the Assay of Plasminogen Activators, Anti-activators, and Plasmin.

Details are given of the selection and standardization of reagents for use in a standard clot method for estimating plasminogen activators, anti-activators, and plasmin.

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پتانسیل آنتی‌پلاسمینوژن منوکلونال آنتی‌بادی در دستکاری دو سیستم فیبرینولیز و آنژیوژنز

Background: Plasminogen has a central role in fibrinolyrtic system can activate through various activators (PAs) to its active form plasmin and perfoem its vital function that is fibrin clot lysis. Furthermore the fibrinolyrtic system plays a major role in angiogenesis. The fibrinolyrtic system activation control cell migration and invasion. In addition to this, plasmin regulates tumor growth. ...

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Bacterial plasminogen activators and receptors.

Invasive bacterial pathogens intervene at various stages and by various mechanisms with the mammalian plasminogen/plasmin system. A vast number of pathogens express plasmin(ogen) receptors that immobilize plasmin(ogen) on the bacterial surface, an event that enhances activation of plasminogen by mammalian plasminogen activators. Bacteria also influence secretion of plasminogen activators and th...

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Pharmacological Influence on the Biosynthesis and Activity of Plasmin, Plasminogen Activators and Their Inhibitor Pai-1

INTRODUCTION Production and activation of proteases, such as matrix metalloproteinases (MMPs), the recently identified aggrecanases (ADAMTS4 and ADAMTS11), and the plasminogen activator (PA)/plasmin system, are involved in the cartilage breakdown process during chronic inflammatory arthritides and osteoarthritis. The PAs are serine proteases, which catalyse the activation of plasminogen to plas...

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Plasminogen activators. The old and the new.

T hrombosis of a coronary or cerebral artery is the most common cause of mortality and morbidity in the developed nations.' The proximate cause is most often atherosclerosis, and the most appropriate intervention is its prevention. Much progress has been made in identifying the risk factors predisposing to atherosclerosis, and, perhaps because of their recognition, a significant decrease in the...

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ژورنال

عنوان ژورنال: Journal of Clinical Pathology

سال: 1964

ISSN: 0021-9746

DOI: 10.1136/jcp.17.2.175